Question 1

Research on the immune response against tumor associated antigens has largely focused on

Accepted Answer

A)  CD4+ T helper cells.
B)  monocytes/macrophages.
C)  B lymphocytes.
D)  CD8+ T suppressor cells.
E)  CD8+ T cytotoxic cells.F) A) and B)
G) B) and E)

Question 2

The tumor associated antigens produced by the MAGE genes fall into which category?

Accepted Answer

A)  Nonmutated, shared, overexpressed antigens
B)  Melanoma- melanocyte differentiation antigens
C)  Mutated antigens
D)  Cancer- testes antigens
E)  Tumor virus antigensF) C) and D)
G) A) and C)

Question 3

Describe how antibodies to cancer are being used to identify potential tumor associated antigens.

Accepted Answer

Recombinant DNA libraries from tumor cel...

Question 4

Development of a "cancer vaccine" is difficult at least in part because there are so many mechanisms by which cancer cells can evade the immune response.

Accepted Answer

A) True 
 B)False

Question 5

Burkitt's lymphoma is associated with ________ virus.

Accepted Answer

The answer of Burkitt's lymphoma is associated with ________ virus....

Question 6

In a given species, when chemical carcinogens cause histologically identical tumors, these tumors can

Accepted Answer

A)  possess completely different tumor antigens.
B)  possess the same tumor antigens.
C)  be successfully transplanted between members of the same species.
D)  A and B.
E)  B and C.F) A) and D)
G) None of the above

Question 7

In which situation(s) is (are) immunotherapy most likely to be effective and worthwhile against a cancer?

Accepted Answer

A)  When the cancer is at high risk for reoccurrence
B)  After debulking of a tumor and standard chemotherapy or radiation therapy
C)  When eliminating minimal residual disease is necessary
D)  All of the aboveE) B) and C)
F) A) and B)

Question 8

The product of the MAGE- 1 gene that was discovered in melanomas is not expressed in normal tissue or tumors from other cell lines.

Accepted Answer

A) True 
 B)False

Question 9

Explain how viruses are postulated to cause cancer.

Accepted Answer

Many viruses that are associated with ca...

Question 10

What is the difference between a tumor specific antigen (TSA) and a tumor associated antigen (TAA) ?

Accepted Answer

A)  TSAs are never found in normal tissue, and TAAs can be found in both normal tissue and tumor tissue.
B)  There is no difference and these terms can be used interchangeably.
C)  TAAs are never found in normal tissue, and TSAs can be found in both normal tissue and tumor tissue.
D)  TSAs are only found on malignant tumors, and TAAs are only found on benign tumors.E) A) and B)
F) A) and C)

Question 11

The majority of in vitro research on the human immune response against tumor cells has been conducted on cell lines propagated from

Accepted Answer

A)  melanomas.
B)  liver adenocarcinomas.
C)  lung carcinomas.
D)  breast adenocarcinomas.
E)  colon adenocarcinomas.F) C) and D)
G) A) and B)

Question 12

A malignant tumor of a muscle would be classified as a

Accepted Answer

A)  myeloma.
B)  sarcoma.
C)  adenocarcinoma.
D)  adenoma.
E)  carcinoma.F) None of the above
G) B) and E)

Question 13

The process in which viral, environmental, and physical factors convert normal cells to tumor cells is called cellular ________.

Accepted Answer

The answer of The process in which viral, environmental, and...

Question 14

What evidence is there that hormones can influence whether a person develops cancer?

Accepted Answer

Women have an increased risk of breast c...

Question 15

Most nonviral tumor associated antigens are very close in structure to normal human antigens.

Accepted Answer

A) True 
 B)False

Question 16

All of the following are cancers of white blood cells except

Accepted Answer

A)  lymphoma.
B)  leukemia.
C)  retinoblastoma.
D)  myeloma.E) C) and D)
F) B) and C)

Question 17

One cancer immunotherapy that has been attempted is pulsing ________ with peptides to increase cytotoxic T lymphocyte activity against tumor cells.

Accepted Answer

A)  B lymphocytes
B)  T helper cells
C)  dendritic cells
D)  natural killer cells
E)  monocyte/macrophagesF) B) and E)
G) A) and D)

Question 18

The tumors caused by specific oncogenic viruses usually express the same tumor antigens.

Accepted Answer

A) True 
 B)False

Question 19

What is (are) advantage(s) of identifying a specific tumor associated antigen on a particular tumor?

Accepted Answer

A)  A monoclonal antibody can be used to fight the tumor.
B)  A monoclonal antibody coupled to a cytotoxin can be used to fight the tumor.
C)  A monoclonal antibody coupled to a radioisotope can be used to fight the tumor.
D)  All of the above.E) B) and C)
F) None of the above

Question 20

Which of the following is a good strategy for developing trial cancer vaccines?

Accepted Answer

A)  Combine all the known tumor associated antigens into a single vaccine and administer it to a random population of healthy adults.
B)  Target populations that have a particular cancer and create a vaccine using tumor associated antigens common to that particular cancer.
C)  Combine all the known tumor associated antigens into a single vaccine and administer it to a random population of cancer patients.
D)  Target healthy populations that are genetically predisposed to developing a particular cancer and create a vaccine using tumor associated antigens common to that particular cancer.E) A) and D)
F) B) and D)

Exam 10: Tumor Immunology

What evidence is there that hormones can influence whether a person develops cancer?

Correct AnswerverifiedWomen have an increased risk of breast c...View AnswerShow Answer

All of the following are cancers of white blood cells except

Correct AnswerverifiedShow Answer

Describe how antibodies to cancer are being used to identify potential tumor associated antigens.

Correct AnswerverifiedRecombinant DNA libraries from tumor cel...View AnswerShow Answer

Which of the following is a good strategy for developing trial cancer vaccines?

Correct AnswerverifiedShow Answer

Burkitt's lymphoma is associated with ________ virus.

Correct AnswerverifiedShow Answer

The product of the MAGE- 1 gene that was discovered in melanomas is not expressed in normal tissue or tumors from other cell lines.

Correct AnswerverifiedShow Answer

One cancer immunotherapy that has been attempted is pulsing ________ with peptides to increase cytotoxic T lymphocyte activity against tumor cells.

Correct AnswerverifiedShow Answer

In a given species, when chemical carcinogens cause histologically identical tumors, these tumors can

Correct AnswerverifiedShow Answer

A malignant tumor of a muscle would be classified as a

Correct AnswerverifiedShow Answer

What is (are) advantage(s) of identifying a specific tumor associated antigen on a particular tumor?

Correct AnswerverifiedShow Answer

The tumor associated antigens produced by the MAGE genes fall into which category?

Correct AnswerverifiedShow Answer

The process in which viral, environmental, and physical factors convert normal cells to tumor cells is called cellular ________.

Correct AnswerverifiedShow Answer

Development of a "cancer vaccine" is difficult at least in part because there are so many mechanisms by which cancer cells can evade the immune response.

Correct AnswerverifiedShow Answer

The majority of in vitro research on the human immune response against tumor cells has been conducted on cell lines propagated from

Correct AnswerverifiedShow Answer

The tumors caused by specific oncogenic viruses usually express the same tumor antigens.

Correct AnswerverifiedShow Answer

Most nonviral tumor associated antigens are very close in structure to normal human antigens.

Correct AnswerverifiedShow Answer

In which situation(s) is (are) immunotherapy most likely to be effective and worthwhile against a cancer?

Correct AnswerverifiedShow Answer

Explain how viruses are postulated to cause cancer.

Correct AnswerverifiedMany viruses that are associated with ca...View AnswerShow Answer

What is the difference between a tumor specific antigen (TSA) and a tumor associated antigen (TAA) ?

Correct AnswerverifiedShow Answer

Research on the immune response against tumor associated antigens has largely focused on

Correct AnswerverifiedShow Answer

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Women have an increased risk of breast c...
View Answer

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Recombinant DNA libraries from tumor cel...
View Answer

Correct Answer
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Correct Answer
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Many viruses that are associated with ca...
View Answer

Correct Answer
verified

Correct Answer
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