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Sickle-cell disease has a physiological impact on the body because it


A) can cause anemia to develop.
B) changes the shape of red blood cells, which decreases the oxygen supply to the tissue.
C) decreases the amount of oxygen picked up by red blood cells from the alveoli.
D) All of the answer choices are correct.

E) A) and B)
F) C) and D)

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At which point of the respiratory system would sickle-cell disease cause an impact?


A) Inhalation of air into the nasal cavity
B) The flow of air down the trachea
C) The delivery of air into the alveoli
D) The diffusion of gases across the alveoli into the capillaries

E) B) and C)
F) B) and D)

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Sickle-cell disease results in malformed hemoglobin molecules. Which cell type contains millions of hemoglobin molecules per cell?


A) Red blood cells
B) White blood cells
C) Neurons
D) Osteoblasts

E) A) and C)
F) A) and B)

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During elongation in transcription, RNA polymerase creates a complementary mRNA sequence from a gene. Provide the mRNA sequence from the given gene sequence. TACGGCACCCAGCATT

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In the human life cycle, gametes are formed through the process of ______, and all other cells are formed through the process of ______.


A) meiosis; mitosis
B) mitosis; meiosis
C) binary fission; mitosis
D) meiosis; binary fission

E) None of the above
F) A) and C)

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In gene expression, step one, also known as ______, converts a gene into mRNA.

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Which of the following statements best describes how a mutation changes the shape of a protein?


A) If a mutation occurs during DNA replication, the affected gene will always produce a protein that is misfolded.
B) If a mutation occurs during DNA replication, the affected gene may produce a protein that is misfolded.
C) If a mutation occurs during DNA replication, the affected gene will never produce a protein that is misfolded.

D) A) and C)
E) None of the above

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Images of unreplicated chromosomes that allow researchers to organize and identify each chromosome, as well as missing or extra chromosomes are called __________.


A) karyotypes
B) punnett squares
C) amniocentesis
D) chorionic villus sampling (CVS)

E) A) and B)
F) B) and C)

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You are given an assignment to identify a pair of human sex chromosomes from a karotype. How would you differentiate the sex chromosomes from the autosomal chromosomes?


A) The sex chromosomes will be labeled XX or XY.
B) The sex chromosomes always contain different lengths. One chromosome is shorter than the other.
C) The sex chromosomes are always the same length and shorter than all other pairs of chromosomes on the karyotype.
D) The sex chromosomes are always the same length and longer than all other pairs of chromosomes on the karyotype.

E) B) and D)
F) C) and D)

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Gene therapy can involve the replacement of a defective gene. Which type of vector is used to replace the defective gene in ex vivo gene therapy and not used in in vivo gene therapy?


A) Stem cells
B) Liposomes
C) Virus
D) Bacteria

E) A) and D)
F) B) and D)

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Describe the movement of oxygen and carbon dioxide during gas exchange.


A) Oxygen diffuses out of the lungs into red blood cells and carbon dioxide diffuses out of red blood cells and into the lungs.
B) Carbon dioxide diffuses out of the lungs into red blood cells and oxygen diffuses out of red blood cells and into the lungs.
C) Oxygen diffuses out of the lungs into red blood cells and carbon dioxide diffuses out of red blood cells into the kidney nephrons.
D) Both carbon dioxide and oxygen diffuse out of red blood cells and into the lungs.

E) B) and C)
F) A) and D)

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PCR mimics DNA replication. Which of the following steps of PCR corresponds with the annealing process in DNA replication?


A) Helicase breaking the hydrogen bonds
B) A primer preparing a starting point for DNA polymerase
C) DNA polymerase sythesizing a daughter strand of DNA

D) A) and B)
E) A) and C)

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In the Hershey-Chase experiment, when the bacteria were exposed to phage that contained a35S labeled capsid,


A) the bacteria in the sediment were not radioactive. This proved the capsid of the new viruses depended on the viral DNA.
B) the bacteria in the sediment were not radioactive. This proved the capsid formation depended on the medium it was grown in.
C) the bacteria in the sediment were radioactive. This proved the capsid of the new viruses depended on the viral DNA.
D) the bacteria in the sediment were radioactive. This proved bacteria began making radioactive35S after being previously exposed to it by the phage.

E) B) and C)
F) A) and D)

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What conclusions resulted from the Hershey-Chase experiments?


A) Hershey and Chase concluded that phage were injecting DNA into bacteria and that it was the injected DNA that coded for the manufacturing of new viruses.
B) Hershey and Chase concluded each nucleotide was complementary to another. Adenine was complementary to thymine and guanine was complementary to cytosine.
C) Hershey and Chase concluded the structure of DNA was a double helix and was held together by hydrogen bonds.
D) Hershey and Chase concluded the two strands of DNA ran opposite of each other in order to bind together.

E) B) and C)
F) A) and C)

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Which of the following statements best describes the structure and function of hemoglobin in the respiratory and circulatory systems?


A) The hemoglobin molecule consists of four alpha globin polypeptide chains and iron molecules that are involved in gas exchange between the blood capillaries and the alveoli capillaries.
B) The hemoglobin molecule consists of four beta globin polypeptide chains and iron molecules that are involved in gas exchange between the alveoli capillaries.
C) The hemoglobin molecule consists of two alpha globin and two beta globin polypeptide chains and iron molecules that are involved in gas exchange between the blood capillaries and the alveoli capillaries.
D) The hemoglobin molecule consists of one alpha globin and three beta globin polypeptide chains and iron molecules that are involved in gas exchange between the blood capillaries and the alveoli capillaries.

E) B) and D)
F) C) and D)

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There are two main forms of non-Mendelian dominance. In ______, as observed in familial hypercholesterolemia, the dominant allele does not completely mask the recessive allele. In ______, as observed in AB blood type, two dominant alleles are expressed for the same phenotype.


A) codominance; incomplete dominance
B) incomplete dominance; codominance
C) recessive; dominant
D) recessive; codominance

E) A) and D)
F) A) and B)

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Several different researchers contributed to the study of the structure of DNA. What did Rosalind Franklin contribute?


A) X-ray crystallography was used to show DNA is a repeating helical structure
B) The percent of adenine is equal to the percent of thymine and the percent of guanine is equal to the percent of cytosine
C) There is a transforming factor that exists and can change bacteria's characteristics
D) Transformation of bacteria did not occur with the addition of DNase enzyme, suggesting DNA is the genetic material

E) A) and C)
F) C) and D)

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Which of the following best describes the definition of a gene?


A) Genetic information that produces a product, either proteins or RNA
B) A section of DNA that produces a single protein product
C) The protein product that genetic material produces
D) A collection of polypeptides that fold to form a complex protein

E) None of the above
F) A) and B)

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PCR is important because it allows scientists to


A) mimic DNA replication to copy a specific segment of DNA to study.
B) track ancestry of organisms.
C) identify criminals in forensic studies.
D) All of the answer choices are correct.

E) A) and D)
F) A) and C)

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The decreased blood flow in the circulartory system can impact the immune and lymphatic systems. A decrease in function of these systems can cause an individual with sickle-cell disease to be more prone to __________.


A) liver disease
B) bacterial and viral infections
C) heart damage
D) kidney failure

E) B) and C)
F) A) and B)

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